Barrett's oesophagus and adenocarcinoma
نویسندگان
چکیده
Address: 1Registrar UK National Barrett's Oesophagus Registry (UKBOR), and Honorary Senior Lecturer, University Department of Surgery, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, UK, 2Joint director UK National Barrett's Oesophagus Registry (UKBOR), and visiting Professor, University Department of Surgery, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, UK, 3MRC Cancer Cell Unit, Hutchison Research Centre, Cambridge, CB2 2XZ, UK and 4Joint director UK National Barrett's Oesophagus Registry (UKBOR) and Group Leader MRC Cancer cell Unit, Hutchison Research Centre, Cambridge, CB2 2XZ, UK
منابع مشابه
Secular trends in the epidemiology and outcome of Barrett's oesophagus in Olmsted County, Minnesota.
BACKGROUND The incidence of oesophageal adenocarcinoma has increased greatly. Barrett's oesophagus is a known risk factor. AIMS To identify changes in the incidence, prevalence, and outcome of Barrett's oesophagus in a defined population. SUBJECTS Residents of Olmsted County, Minnesota, with clinically diagnosed Barrett's oesophagus, or oesophageal or oesophagogastric junction adenocarcinom...
متن کاملDietary factors and the risks of oesophageal adenocarcinoma and Barrett's oesophagus.
Incidence rates for oesophageal adenocarcinoma have increased by over 500% during the past few decades without clear reasons. Gastro-oesophageal reflux disease, obesity and smoking have been identified as risk factors, although the demographic distribution of these risk factors is not consistent with the demographic distribution of oesophageal adenocarcinoma, which is substantially more common ...
متن کاملBarrett's oesophagus: epidemiology, diagnosis and clinical management.
Barrett's oesophagus is a condition characterised by partial replacement of the normal squamous epithelium of the lower oesophagus by a metaplastic columnar epithelium containing goblet cells (intestinal metaplasia). Barrett's oesophagus is important clinically because those afflicted are predisposed to oesophageal adenocarcinoma. Prevalence surveys suggest that up to 2% of the population may b...
متن کاملBarrett's oesophagus and oesophageal adenocarcinoma: how does acid interfere with cell proliferation and differentiation?
Acid, a principal component of gastro-oesophageal refluxate, may contribute to the development and malignant progression of Barrett's oesophagus. Oesophageal pH monitoring studies have demonstrated that patients with Barrett's oesophagus have severe and chronic acid reflux. However, there is overlap between the amount of acid exposure in patients with oesophagitis compared with patients with Ba...
متن کاملAccumulation of p53 protein in normal, dysplastic, and neoplastic Barrett's oesophagus.
Accumulation of p53 protein was determined by immunohistochemistry in archival material of biopsy specimens from 102 patients with Barrett's oesophagus with different grades of dysplasia, in 24 oesophageal adenocarcinomas associated with Barrett's oesophagus, and in 23 cases of metaplastic epithelium adjacent to these carcinomas. Immunostaining for the p53 protein was found in 23/102 (23 per ce...
متن کاملInfluence of Life Style Factors on Barrett's Oesophagus
Background. Since the incidence of adenocarcinoma of the oesophagus is rising, the prognosis is poor, and surveillance programs are expensive and mostly cost ineffective, there is a need to increase the knowledge of risk factors in Barrett's oesophagus and oesophageal cancer in order to be able to give attention to medical prevention and/or surveillance programs. Aim. To study if there is a cor...
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عنوان ژورنال:
- World Journal of Surgical Oncology
دوره 2 شماره
صفحات -
تاریخ انتشار 2004